Genetics of Hyperparathyroidism, Including Parathyroid Cancer

Hyperparathyroidism due to parathyroid carcinoma.

Parathyroid carcinoma in familial hyperparathyroidism.

Two families with hereditary hyperparathyroidism are described. One member of each family developed a parathyroid carcinoma. In one case this recurred locally and metastasised. This patient showed hyperplasia of one of the three other parathyroid glands. It is possible that the different parathyroid lesions found in familial hyperparathyroidism may be the result of a progression from hyperplasi...

Mast cells in parathyroid glands of hyperparathyroidism.

Parathyroid glands from cases of hyperparathyroidism have been examined with particular attention to mast cells. In ;normal' glands accompanying an adenoma they were common, although there was a wide range in their frequency, whereas in pathological tissue, both adenoma and hyperplasia, mast cells were scarce. This difference between glands was examined with respect to alterations in gland size...

Mediastinal parathyroid adenoma causing primary hyperparathyroidism.

An ectopically placed parathyroid adenoma in the anterior mediastinum is a rare cause of persistent or recurrent primary hyperparathyroidism (PHPT) and is recognized as an important cause of failed primary neck exploration. We encountered 3 such cases amongst 70 surgically treated patients with PHPT (4.3%) over a 20-year period. In 2 cases, the offending adenoma could be removed at first explor...

Concurrent Parathyroid Carcinoma and Hyperplasia in Hyperparathyroidism

To the Editor, Parathyroid carcinoma is a rare disease that accounts for less than 1% of all hyperparathyroidism [1]. The incidence of parathyroid carcinoma is extremely low, although the apparent incidence of hyperparathyroidism increased after the introduction of multi-channel autoanalyzers. If increased serum calcium and parathyroid hormone (PTH) levels are sustained postoperatively, metasta...